Cell-mediated immunity and its application in toxicology.

Cell-mediated immunity and its application in toxicology.

A variety of in vivo and more recently in vitro assays have been described to assess cell mediated immunity (CMI). Two methods routinely employed in our laboratory to assess CMI following exposure to chemicals in rodents include delayed hypersensitivity and in vitro lymphoproliferation. Preliminary studies indicate that depressed delayed hypersensitivity responses, as performed by a radiometric...

EVALUATION OF CELL-MEDIATED IMMUNITY IN MUSTARD GAS INJURIES

Yamakido, et al. in 1986 have studied immunological parameters in poison gas workers, and a depression has been observed in immunologic response. Also, the frequency of cancer has reached as high as five-fold that of the general population. In the present study, cell-mediated immunity (CMI) was measured in three groups of Iranian mustard gas-injured patients. The first group were those wh...

Toxicology in its Application to Medical Practice.

EVA LUATION OF THE ROLE OF CELL-MEDIATED IMMUNITY IN DERMATOPHYTOSIS

For demonstration of cell-mediated immunity and its role in the process of dermatophytosis, 98 patients with acute dermatophytosis (group I) and 131 chronic dermatophytosis patients (group 2) were chosen. In ail patients, lymphocyte transfonnation and skin test were used. 96 members of group I (98%) had positive delayed-type hypersensitivity (DTH) responses to trichophytin, whereas only 43 ...

Humoral Immunity and Cell-Mediated Immunity